Beyond Restenosis

Beyond restenosis: five-year clinical outcomes from second-generation coronary stent trials.

BACKGROUND In the first year after coronary stent implantation, clinical failures are driven mainly by procedural complications and restenosis, but the subsequent relative contributions of restenosis and disease progression to late failures are less clear. METHODS AND RESULTS We observed 1228 patients for 5 years after the implantation of stents as part of pivotal second-generation coronary s...

Mitral restenosis.

Tumour radiobiology beyond fractionation

Historically it has been shown repeatedly that single high doses of radiation do not allow a therapeutic differential between tumor and critical normal tissues but dose fractionation does. The purpose of conventional dose fractionation is to increase dose to the tumor while preserving normal tissue function. Tumors are generally irradiated with 2Gy dose per fraction delivered daily to a more or...

Restenosis: delineating the numerous causes of drug-eluting stent restenosis.

In the past decade, tremendous progress has been made in reducing the incidence of restenosis with the advent of the drug-eluting stent (DES). With “plain old balloon angioplasty,” rates of acute and chronic vessel occlusion were unacceptably high at 30% to 60%, secondary to acute and chronic recoil and constrictive remodeling. The advent of bare-metal stents (BMS) appeared to eliminate the iss...

Gilles Deleuze: Beyond Peirce’s Semiotics

This paper studies the role of the semiotic discussions of Charles Sanders Peirce, the American philosopher and mathematician, in the formation of Deleuze’s first leading book on cinema, Cinema 1: the Movement-Image,in whichthe author surpasses Peirce’s semiotics. We will show how Deleuze creates a new form of signs in his second leading book on cinema, Cinema 2: the Time-Image. Deleuze had tri...